Allegra 120 works by blocking histamine, a natural substance in the body that contributes to allergy symptoms like sneezing, itching, and runny nose. Unlike first-generation antihistamines, which can cause sedation, Allegra 120 does not cross the blood-brain barrier significantly, so it does not typically affect the sleep-wake cycle. But for the vast majority, Allegra 120 does not interfere with normal sleep patterns and can be taken safely during the day or even before bedtime without causing wakefulness.

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